Herdox Supplement Facts

Daily Dosage: As a dietary supplement, take one capsule in the morning and one capsule in the afternoon with 8 ounces of water. 45-60 days of continuous use is necessary for optimum results.

Herdox Research:

Vitamin A- Vitamin A is a potent immune stimulatory vitamin. Studies have shown that patients with vitamin A deficiency experience more shedding of the herpes simplex virus (1). As well, isomers of retinoic acid ( a form of vitamin A) have demonstrated the ability to inhibit HSV replication (2).

Vitamin E- Vitamin E is often given with vitamin A to improve the clinical response and reduce possible toxicity associated with high doses of vitamin A. A patented combination of antioxidants containing vitamin E has shown clinical effectiveness in reducing lesion development, duration and severity scores significantly compared to vehicle control or acyclovir (a prescription anti-viral) (3). Studies conducted by dentists have demonstrated vitamin E alone is effective for ulcerative herpetic lesions (4, 5).

Zinc- One of the most important minerals for immune function, zinc has been widely studied for prevention and treatment of infections. A clinical trial showed that systemic zinc sulphate supplementation given a t a dose of 45mg daily during February, March, September and October appeared to reduce both the number of episodes and the time to recovery of herpes labialis over a 12 month period (6). Topical treatment with zinc solutions have also been effective in herpes simplex infections (7, 8).

Selenium- The mineral selenium is also required for basic immune function. The role of selenium in anti-viral medicine is becoming quite clear, as numerous pharmaceutical anti-viral drugs are in the process of creation. A newly designed class of drugs containing selenium exhibit strong inhibition of cythopatic activity of HSV-1 (9).

L-lysine- Classically known as an anti-herpes nutrient, patients suffering from this infection are well aware of the impact of lysine supplementation. Lysine is an effective preventative therapy, as well as a treatment option (10, 11). A clinical trial of an ointment containing lysine, zinc and botanicals revealed full resolution of symptoms in 40%of patients with oral herpes by the third day of treatment and 87%by the sixth day (12).

Monolaurin- Monolaurin is a naturally derived supplement made from lauric acid (a fatty acid in breast milk and coconut milk) and glycerin. It is recommended for viral infections like Epstein-Barr, influenza, measles and herpes as a result of in vitro studies demonstrating anti-viral activity against these and numerous other viruses (13).

Lactoferrin- Lactoferrin is a glycoprotein with many activities. It is an important factor in immune regulation and defense mechanisms against bacteria, fungi, and viruses. Lactoferrin has demonstrated anti-viral activity against HSV-1 and HSV-2 and exhibits synergistic activity with acyclovir against these same viruses (14).

Garlic Powder- Garlic is often described as the panacea of botanical medicine. This common culinary herb exhibits anti-viral activity against many viruses including HSV-1 and HSV-2 (15).

Lemon Balm Powder- Melissa officinalis is widely known in Germany for its potent anti-viral activity and is recommended for many infections, including influenza and herpes. This herb contains numerous components that inhibit replication of HSV-1 and HSV-2 (16, 17). Many topical preparations contain lemon balm which is an effective treatment for recurring herpes labialis and can reduce frequency of subsequent outbreaks (18).

Olive Leaf Extract- Olea europea is a relatively new recommended herb for conditions of an infectious nature. It has demonstrated anti-viral activity against HIV and viral haemorrhagic septicaemia virus (19, 20). Researchers believe olive leaf may be a promising source of natural anti-viral compounds.

Propolis Extract- Propolis is a naturally occurring product derived from beehives which contains a large flavonoid component. It displays anti-HSV-1 activity both in vitro and in vivo (21). Propolis may prevent the virus from adhering to host cells and also prevent replication of the virus. In a multi-center study, a preparation of propolis demonstrated superior activity over both acyclovir and placebo ointments in healing genital herpetic lesions, and in reducing local symptoms (22).

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Herdox References:

1. Mostad SB et al. Cervical shedding of herpes simplex virus in human immunodeficiency virus-infected women: effects of hormonal contraception, pregnancy, and vitamin A deficiency. J Infect Dis. 2000 Jan;181(1):58-63.

2. Issacs CE et al. Inhibition of herpes simplex virus replication by retinoic acid. Antiviral Res. 1997 Jan;33(2):117-27.

3. Sheridan J et al. Evaluation of antioxidant healing formulations in topical therapy of experimental cutaneous and genital herpes simplex virus infections. Antiviral Res. 1997 Dec;36(3):157-66.

4. Nead DE. Effective vitamin E treatment for ulcerative herpetic lesions. Dent Surv. 1976 Jul;52(7):50-1.

5. Fink M and Fink J. Treatment of herpes simplex by alpha-tocopherol (vitamin E). Br Dent J 1980;148:246.

6. Femiano F, Gombos F and Scully C. Recurrent herpes labialis: a pilot study of the efficacy of zinc therapy.J Oral Pathol Med. 2005 Aug;34(7):423-5.

7. Wabba A. topical application of zinc solutions: a new treatment for herpes simplex infections of the skin. Acta Derm Venereol 1980;60:175.

8. Tennican P et al. Topical zinc in the treatment of mice infected intravaginally with herpes genitalis virus. Proc Soc Exp Biol Med 1980;164:593.

9. Wojtowicz H et al. Azaanalogues of ebselen as antimicrobial and antiviral agents: synthesis and properties.Farmaco. 2004 Nov;59(11):863-8.

10. Milman N and Scheibel J. Lysien prophylaxis in recurrent herpes simplex labilais: a double blind crossover study. Acta Derm Venereol 1980;60:85.

11. Kagan C. Lysine therapy for herpes simplex. Lancet 1974;1:137.

12. Singh BB et al. Safety and effectiveness of an L-lysine, zinc, and herbal-based product on the treatment of facial and circumoral herpes.Altern Med Rev. 2005 Jun;10(2):123-7.

13. Hierholzer JC and Kabara JJ. In vitro effects of Monolaurin compounds on enveloped RNA and DNA viruses. J. Food Safety 4:1, 1982.

14. Andersen JH, Jenssen H and Gutteberg TJ. Lactoferrin and lactoferricin inhibit Herpes simplex 1 and 2 infection and exhibit synergy when combined with acyclovir. Antiviral Res. 2003 May;58(3):209-15.

15. Weber ND et al. In vitro virucidal effects of Allium sativum (garlic) extract and compounds. Planta Med. 1992 Oct;58(5):417-23.

16. Allahverdiyev A et al. Antiviral activity of the volatile oils of Melissa officinalis L. against Herpes simplex virus type-2.Phytomedicine. 2004 Nov;11(7-8):657-61.

17. Dimitrova Z et al. Antiherpes effect of Melissa officinalis L. extracts. Acta Microbiol Bulg. 1993;29:65-72.

18. Koytchev R, Alken Rg and Dundarov S. Balm mint extract (Lo-701) for topical treatment of recurring herpes labialis. Phytomedicine. 1999 Oct;6(4):225-30.

19. Lee-huang S et al. Anti-HIV activity of olive leaf extract (OLE) and modulation of host cell gene expression by HIV-1 infection and OLE treatment. Biochem Biophys Res Commun. 2003 Aug 8;307(4):1029-37

20. Micol V et al. The olive leaf extract exhibits antiviral activity against viral haemorrhagic septicaemia rhabdovirus (VHSV). Antiviral Res. 2005 Jun;66(2-3):129-36. Epub 2005 Apr 18.

21. Huleihel M and Isanu V. Anti-herpes simplex virus effect of an aqueous extract of propolis. Isr Med Assoc J. 2002 Nov;4(11 Suppl):923-7.

22. Vynograd N, Vynograd I and Sosnowski Z. A comparative multi-centre study of the efficacy of propolis, acyclovir and placebo in the treatment of genital herpes (HSV). Phytomedicine. 2000 Mar;7(1):1-6.

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